Post-Exposure Protocol
Time-critical intervention strategy for use after known or suspected exposure
Why Post-Exposure Protocol?
Time-Critical Intervention
Post-exposure protocol is most effective when initiated within 24-48 hours of known or suspected exposure for optimal results.
Two-Dose Strategy
Strategic two-dose approach spaced 48 hours apart provides comprehensive coverage during the critical exposure window.
Rapid Response
Higher initial dose (0.4 mg/kg) provides immediate therapeutic levels to address potential exposure quickly.
Flexible Application
Can be used after known exposure events or as precautionary measure when exposure is suspected but not confirmed.
Post-Exposure Timeline
Critical timing guide for implementing the post-exposure protocol effectively
Immediate Response
Take first dose as soon as possible after known or suspected exposure. Earlier administration provides better outcomes.
Monitoring Period
Monitor for any early symptoms while waiting for second dose. Stay hydrated and rest. Document any changes.
Second Dose
Administer second dose exactly 48 hours after the first dose to maintain therapeutic coverage.
Post-Protocol Monitoring
Continue monitoring for symptoms. Most people remain symptom-free. Seek medical attention if symptoms develop.
Post-Exposure Dosage Chart
Reference chart for 0.4 mg/kg post-exposure dosing. Each dose in the two-dose protocol uses this amount.
| Body Weight | Dose Per Administration | 3mg Tablets | 6mg Tablets | 12mg Tablets |
|---|---|---|---|---|
| 110 lbs (50 kg) | 20 mg | 7 tablets | 3-4 tablets | 2 tablets |
| 132 lbs (60 kg) | 24 mg | 8 tablets | 4 tablets | 2 tablets |
| 154 lbs (70 kg) | 28 mg | 9-10 tablets | 5 tablets | 2-3 tablets |
| 176 lbs (80 kg) | 32 mg | 11 tablets | 5-6 tablets | 3 tablets |
| 198 lbs (90 kg) | 36 mg | 12 tablets | 6 tablets | 3 tablets |
| 220 lbs (100 kg) | 40 mg | 13-14 tablets | 7 tablets | 3-4 tablets |
Two-Dose Protocol Reminder:
Take the first dose immediately after exposure, then take the second dose of the same amount exactly 48 hours later. Both doses should be taken on an empty stomach for optimal absorption.
When to Use Post-Exposure Protocol
Common exposure scenarios where the post-exposure protocol may be appropriate
Close Contact Exposure
Extended close contact (within 6 feet for 15+ minutes) with someone who later tested positive or showed symptoms.
Household Exposure
Living with or caring for someone who is actively symptomatic or has confirmed infection.
Healthcare Setting
Potential exposure in medical facilities, clinics, or while caring for patients.
Travel Exposure
Extended travel in enclosed spaces (planes, buses, trains) with potentially exposed individuals.
Workplace Exposure
Notification of positive case in workplace with shared spaces or close working proximity.
Event Exposure
Attendance at gatherings, events, or social functions where exposure may have occurred.
Enhanced Post-Exposure Protocol
Optional combination approach with supportive supplements. Mebendazole may be added if parasitic co-exposure is suspected.
| Medication/Supplement | Dose | Timing | Notes |
|---|---|---|---|
| Ivermectin | 0.4 mg/kg | Dose 1: Immediately, Dose 2: 48 hours later | Primary post-exposure prophylaxis |
| Mebendazole | 100 mg | Twice daily for 3 days (if parasitic co-exposure suspected) | Optional addition for comprehensive coverage |
| Vitamin D3 | 5,000-10,000 IU | Daily during exposure period | Immune support supplement |
| Zinc | 50 mg | Daily with food | Supports immune function |
| Vitamin C | 1,000-2,000 mg | Divided doses throughout day | Antioxidant support |
Note: Both Ivermectin and Mebendazole are available from JASE Medical. Mebendazole is primarily used for parasitic infections but may provide additional coverage in certain exposure scenarios. Consult with a healthcare provider for personalized recommendations.
Frequently Asked Questions
How soon after exposure should I start the protocol?
The post-exposure protocol is most effective when started within 24-48 hours of known or suspected exposure. Earlier initiation generally leads to better outcomes. If more than 72 hours have passed, consult with a healthcare provider about whether to proceed or consider alternative approaches.
What if I am not sure I was exposed?
If exposure is uncertain but possible (e.g., you were in a high-risk environment or learned of cases in your vicinity), you may consider the protocol as a precautionary measure. Discuss with your healthcare provider to weigh the benefits against your individual risk factors.
Can I take the second dose early or late?
The 48-hour interval is designed for optimal therapeutic coverage. Taking the second dose a few hours early or late is generally acceptable, but try to stay as close to the 48-hour mark as possible. Do not take both doses on the same day.
What if I develop symptoms after starting the protocol?
If symptoms develop after initiating the post-exposure protocol, you may need to transition to the Active Treatment Protocol with higher doses and longer duration. Contact your healthcare provider immediately for guidance on adjusting your treatment approach.
Can I use this protocol repeatedly for multiple exposures?
Yes, the post-exposure protocol can be used for separate exposure events. However, if you are experiencing frequent exposures, you may want to consider transitioning to a Preventive Protocol for ongoing protection rather than repeated post-exposure treatments.
Should I combine Ivermectin with Mebendazole for post-exposure?
Mebendazole is primarily an antiparasitic and is not typically needed for viral post-exposure prophylaxis. However, if you suspect parasitic co-exposure (e.g., travel to endemic areas), combining both medications may provide comprehensive coverage. Consult your healthcare provider.
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Medical Disclaimer
This information is provided for educational purposes only and is not intended as medical advice. The post-exposure protocol described is based on published clinical research and should only be implemented under the guidance of a qualified healthcare professional.
Post-exposure prophylaxis timing is critical. If you believe you have been exposed to a serious illness, seek immediate medical attention. Individual treatment plans may vary based on health status, exposure type, and other factors. This page contains affiliate links to JASE Medical products.